abstract::Background/Aims. Despite the high efficacy and safety of direct-acting antivirals against hepatitis C virus shown in clinical trials, treatment failures continue to occur. Our aim was to establish the effectiveness of these drugs in routine clinical practice, as well as to determine factors that could influence the re...
journal_title:The Libyan journal of medicinepub_type: 杂志文章
doi:10.1080/19932820.2021.1949797
更新日期:2021-12-01 00:00:00
abstract::Circular RNAs (circRNAs) are a class of novel non-coding RNAs that are vital in modulating gene expression and biological processes. Nevertheless, in cervical cancer (CC), the role of circRNA is much less investigated. In this work, circ_0000228 expression in CC is measured and circ_0000228's function and related mech...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1954846
更新日期:2021-12-01 00:00:00
abstract:AIMS:To investigate the association between overweight/obesity and fatty liver index (FLI) on the odds of incident prediabetes/type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) in 2020 participants after 10 years follow up. METHODS:At baseline (in 2001) 2020 participants, males and females, aged 24-39 year...
journal_title:Annals of medicinepub_type: 杂志文章
doi:10.1080/07853890.2021.1956685
更新日期:2021-12-01 00:00:00
abstract::Purpose: To deepen the understanding of how survivors' experience and give meaning to the embodied phenomenon of chronic sensory disturbances in everyday life after oxaliplatin treatment for colorectal cancer.Methods: Data was generated by means of a semi-structured interview guide and drawings with the aim to explore...
journal_title:International journal of qualitative studies on health and well-beingpub_type: 杂志文章
doi:10.1080/17482631.2021.1950889
更新日期:2021-12-01 00:00:00
abstract::FAM83D has been demonstrated to contribute to tumorigenesis. However, its immune effects in hepatocellular carcinoma (HCC) have not been reported. This study aimed to identify the immune role of FAM83D in HCC. FAM83D was over-expressed in HCC and contributed to poor prognosis according to the results of data analysis ...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1950260
更新日期:2021-12-01 00:00:00
abstract::Although rates of substance use are higher in the Canadian territories than the provinces, there is little research on cannabis use. This exploratory study describes cannabis use and related risk behaviours among alcohol consumers in Whitehorse (Yukon) and Yellowknife (Northwest Territories), with comparisons to data ...
journal_title:International journal of circumpolar healthpub_type: 杂志文章
doi:10.1080/22423982.2021.1948254
更新日期:2021-12-01 00:00:00
abstract::Nonsteroidal aromatase inhibitors (NSAIs) are well-established drugs for the therapy of breast cancer. However, they display some serious side effects, and their efficacy can be compromised by the development of chemoresistance. Previously, we have reported different indazole-based carbamates and piperidine-sulphonami...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2021.1954918
更新日期:2021-12-01 00:00:00
abstract::Medicine use is a cornerstone in the treatment of many conditions, but ill-use has the potential to harm the patient. Thus, accurate medication information is critical for patient care and safety. To investigate the association between participants' reporting of using medicine daily, medicine list on Electronic Medica...
journal_title:International journal of circumpolar healthpub_type: 杂志文章
doi:10.1080/22423982.2021.1955493
更新日期:2021-12-01 00:00:00
abstract::Oral squamous cell carcinoma (OSCC) is one of the most common digestive tumors, which has high mortality rate. Long non-coding RNAs (lncRNA) and MicroRNAs (miRNAs) are associated with the cell cycle and differentiation during the occurrence and development of malignant tumors. This research aimed to investigate the ef...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1950278
更新日期:2021-12-01 00:00:00
abstract::Glioblastoma (GBM) is a common malignant tumor of the brain. Members of the carbohydrate sulfotransferase (CHST) family are deregulated in various cancer types. However, limited data are available on the role of the members of the CHST family in the development of GBM. The present study aimed to identify the role of s...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1944455
更新日期:2021-12-01 00:00:00
abstract::The aim of this research was to screen the ZINC15 database to select lead compounds and drug candidates which can inhibit B-RAF (V600E). In order to identify drugs potentially inhibited B-RAF (V600E), numerous modules of Discovery Studio 4.5 were employed. Structure-based screening using LibDock was carried out follow...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1943113
更新日期:2021-12-01 00:00:00
abstract::COVID-19 can cause serious respiratory complications resulting in the need for invasive ventilatory support and concurrent aerosol therapy. Aerosol therapy is considered a high risk procedure for the transmission of patient derived infectious aerosol droplets. Critical-care workers are considered to be at a high risk ...
journal_title:Drug deliverypub_type: 杂志文章
doi:10.1080/10717544.2021.1951893
更新日期:2021-12-01 00:00:00
abstract::Dysfunction of airway smooth muscle (ASM) cells is crucial in asthma pathogenesis. Here, microRNA-30b-5p (miR-30b-5p)'s function and mechanism in ASM cells' multiplication and migration were investigated. Microarray was utilized for identifying the differentially expressed miRNAs in the bronchial epithelial cells of t...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1950401
更新日期:2021-12-01 00:00:00
abstract::In this paper, with eclipse stage in consideration, we propose an HIV-1 infection model with a general incidence rate and CTL immune response. We first study the existence and local stability of equilibria, which is characterized by the basic infection reproduction number R0 and the basic immunity reproduction number ...
journal_title:Journal of biological dynamicspub_type: 杂志文章
doi:10.1080/17513758.2021.1950224
更新日期:2021-12-01 00:00:00
abstract::Aging is a major risk factor for spermatogenesis deterioration. However, the influence of age on spermatogenic stem cells and their progenitors in bulls is largely unknown. Here, we report age-related changes in undifferentiated and differentiating spermatogonia in Japanese Black cattle with nearly constant sperm outp...
journal_title:Animal science journal = Nihon chikusan Gakkaihopub_type: 杂志文章
doi:10.1111/asj.13572
更新日期:2021-12-01 00:00:00
abstract:PURPOSE:Although participation is key to community mental health, the concept remains elusive. The study explored a conceptualization of participation in the community-based mental health agencies context from a first-person perspective, using the Clubhouse model as an example. METHODS:Qualitative data, collected from...
journal_title:International journal of qualitative studies on health and well-beingpub_type: 杂志文章
doi:10.1080/17482631.2021.1950890
更新日期:2021-12-01 00:00:00
abstract::Gestational diabetes mellitus (GDM) increases the risk of fetal heart malformations, though little is known about the mechanism of hyperglycemia-induced heart malformations. Thus, we aimed to reveal the global landscape of miRNAs and mRNAs in GDM-exposed fetoplacental arterial endothelial cells (dAECs) and establish r...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1950279
更新日期:2021-12-01 00:00:00
abstract::With the rapid development of the electronics industry, high-density electronic devices and component mounting have gained popularity. Because of the heat generated from these devices, efficiency of the electronic parts is significantly lowered and life of various electronic devices is considerably shortened. Therefor...
journal_title:Journal of nanoscience and nanotechnologypub_type: 杂志文章
doi:10.1166/jnn.2021.19512
更新日期:2021-12-01 00:00:00
abstract::Cadmium sulfide (CdS), an II-VI group semiconductor material, is one of the most investigated semiconductors in thin film form. In this work, we synthesized CdS thin films with improved film morphology in the presence of ethylene diamine (EA) as the complexing agent by chemical bath deposition (CD) at lower pH. Detail...
journal_title:Journal of nanoscience and nanotechnologypub_type: 杂志文章
doi:10.1166/jnn.2021.19521
更新日期:2021-12-01 00:00:00
abstract::The function of lncRNA CRNDE and its role in prostate cancer (PC) remains unclear. The aim of this study was to determine the expression level of lncRNA CRNDE in PC tissues and to elucidate its role in PC. The expression levels of lncRNA CRNDE were measured by quantitative reverse transcription polymerase chain reacti...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1935402
更新日期:2021-12-01 00:00:00
abstract::This study aimed to investigate the effects of DMSO@γ-Fe₂O₃ nanomagnetic fluid thermotherapy combined with the chemotherapy drug carmustine on cervical cancer cells under a certain intensity of alternating magnetic field. And the role of Mir-590-3P in the development and progression of cervical cancer. The optimal the...
journal_title:Journal of nanoscience and nanotechnologypub_type: 杂志文章
doi:10.1166/jnn.2021.18596
更新日期:2021-12-01 00:00:00
abstract::Age-related skeletal muscle deterioration (sarcopenia) has a significant effect on the elderly's health and quality of life, but the molecular and gene regulatory mechanisms remain largely unknown. It is necessary to identify the candidate genes related to skeletal muscle aging and prospective therapeutic targets for ...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1948951
更新日期:2021-12-01 00:00:00
abstract::In this work, we have synthesized a nanocomposite ZnS/CdS/Pt/TiO₂ nanotube arrays (denoted ZCP-NTAs). Firstly, TiO₂ nanotube array (NTAs) material was fabricated by the anodic method of a titanium plate in an electrolyte solution containing 0.35 M NaHSO₄ and 0.24 M NaF and incubated in the air at 500 ºC for 2 hours. A...
journal_title:Journal of nanoscience and nanotechnologypub_type: 杂志文章
doi:10.1166/jnn.2021.19531
更新日期:2021-12-01 00:00:00
abstract::The usefulness of carboxymethyl cellulose (CMC) as a matrix material in enhancing the controlled release formulations of bispyribac (BP) herbicide from the interlayer gallery of zinc hydroxide nitratesodium dodecylsulphate-bispyribac (ZHN-SDS-BP) nanocomposite was investigated. The CMC coated nanocomposite, ZHN-SDS-BP...
journal_title:Journal of nanoscience and nanotechnologypub_type: 杂志文章
doi:10.1166/jnn.2021.19499
更新日期:2021-12-01 00:00:00
abstract::Acute myocardial infarction (AMI) was considered a fatal disease resulting in high morbidity and mortality; platelet activation or aggregation plays a critical role in participating in the pathogenesis of AMI. The current study aimed to reveal the underlying mechanisms of platelets in the confrontation of AMI and pote...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1937906
更新日期:2021-12-01 00:00:00
abstract::Interactions between prion protein (PrP) and tau protein have long been discussed, especially in relation to the pathogenesis of neurodegenerative diseases. The presence of tauopathy in the genetic forms of Creutzfeldt-Jakob disease (CJD) brains is not uncommon. Molecular interactions between PrP and tau protein have ...
journal_title:Prionpub_type: 杂志文章
doi:10.1080/19336896.2021.1946378
更新日期:2021-12-01 00:00:00
abstract:CONTEXT:The phosphorylation of signal transducer and activator of transcription protein 3 (STAT3) is up-regulated in glioblastoma (GBM) cells and is regulated by protein tyrosine phosphatase receptor type M (PTPRM). Fibronectin-1 (FN1) is also reported to be up-regulated in GBM. OBJECTIVE:We explored the role of FN1-i...
journal_title:Pharmaceutical biologypub_type: 杂志文章
doi:10.1080/13880209.2021.1944220
更新日期:2021-12-01 00:00:00
abstract:CONTEXT:Baicalein and simvastatin possess similar pharmacological activities and indications. The risk of their co-administration was unclear. OBJECTIVE:The interaction between baicalein and simvastatin was investigated to provide reference and guidance for the clinical application of the combination of these two drug...
journal_title:Pharmaceutical biologypub_type: 杂志文章
doi:10.1080/13880209.2021.1942927
更新日期:2021-12-01 00:00:00
abstract:PURPOSE:Our present study was a qualitative investigation intending to explore the emotional journey of wives whose spouse has been diagnosed with Bipolar I Disorder, using a phenomenological design. METHOD:Semi-structured face to face interviews were conducted with 5 wives of already diagnosed Bipolar I Disorder pati...
journal_title:International journal of qualitative studies on health and well-beingpub_type: 杂志文章
doi:10.1080/17482631.2021.1946926
更新日期:2021-12-01 00:00:00
abstract::Mirolysin is a secretory protease of Tannerella forsythia, a member of the dysbiotic oral microbiota responsible for periodontitis. In this study, we show that mirolysin latency is achieved by a "cysteine-switch" mechanism exerted by Cys23 in the N-terminal profragment. Mutation of Cys23 shortened the time needed for ...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2021.1937619
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:The liver fat score (LFS) has been proposed to be a simple non-invasive marker of non-alcoholic fatty liver disease (NAFLD), which is highly prevalent in the general population. We tested its association with cardiovascular diseases (CVDs) and prognosis. METHODS:17,244 adult participants from the National H...
journal_title:Annals of medicinepub_type: 杂志文章
doi:10.1080/07853890.2021.1943514
更新日期:2021-12-01 00:00:00
abstract::Targeted treatment of cerebral ischemia/reperfusion injury (CIRI) remains a problem due to the difficulty in drug delivery across the blood-brain barrier (BBB). In this study, we developed Bo-TSA-NP, a novel tanshinone IIA (TSA) loaded nanoparticles modified by borneol, which has long been proved with the ability to e...
journal_title:Drug deliverypub_type: 杂志文章
doi:10.1080/10717544.2021.1943058
更新日期:2021-12-01 00:00:00
abstract:Background:Various factors, inherited and acquired, are associated with habitual spinal postures. Objective:The purpose of this study was to identify the relationships between trunk muscle endurance, anthropometry and physical activity/inactivity and the sagittal standing lumbopelvic posture in pain-free young partici...
journal_title:Hong Kong physiotherapy journal : official publication of the Hong Kong Physiotherapy Association Limited = Wu li chih liaopub_type: 杂志文章
doi:10.1142/S1013702521500128
更新日期:2021-12-01 00:00:00
abstract::This study examined whether activation of zinc finger protein 750/Ras-related C3 botulinum toxin substrate 1 (ZNF750/RAC1) signaling pathway may be involved in the ability of resveratrol to inhibit malignant progression of CAL-27 oral squamous cell carcinoma cells. CAL-27 cells were treated with resveratrol and transf...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1940616
更新日期:2021-12-01 00:00:00
abstract::Chemotherapy plays a major role in the treatment of cancer, but it still has great limitations in anti-tumor effect. Carboplatin (CAR) is the first-line drug in the treatment of non-small cell lung cancer, but the therapeutic effect is demonstrated weak. Therefore, we modified CAR with hexadecyl chain and polyethylene...
journal_title:Drug deliverypub_type: 杂志文章
doi:10.1080/10717544.2021.1938754
更新日期:2021-12-01 00:00:00
abstract::The cochlea's inaccessibility and complex nature provide significant challenges to delivering drugs and other agents uniformly, safely and efficiently, along the entire cochlear spiral. Large drug concentration gradients are formed along the cochlea when drugs are administered to the middle ear. This undermines the ma...
journal_title:Drug deliverypub_type: 杂志文章
doi:10.1080/10717544.2021.1943059
更新日期:2021-12-01 00:00:00
abstract::Virulence attenuation frequently occurs in in vitro culturing of pathogenic microbes. In this study, we investigated the total putative long noncoding RNAs (lncRNAs) in an aphid-obligate pathogen, Conidiobolus obscurus, and screened the differentially expressed (DE) lncRNAs and protein-coding genes involved in the vir...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2021.1938806
更新日期:2021-12-01 00:00:00
abstract::MicroRNAs (miRNAs) play a very important role in the development of acute myeloid leukemia (AML). This study focuses on the effects of miR-9 on the regulation of AML cells and their related signaling pathways. We found that the expression of miR-9 was significantly decreased in four AML cell lines (THP-1, HL-60, TF-1 ...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1915727
更新日期:2021-12-01 00:00:00
abstract:CONTEXT:Since ancient times, traditional Arabic medicine (TAM) has been used to treat various diseases in Syria. They are cost-effective with fewer side effects and are more suitable for long-term use compared with chemically synthesized medicines. In addition, the scientific importance is manifested, as this survey pr...
journal_title:Pharmaceutical biologypub_type: 杂志文章
doi:10.1080/13880209.2021.1936078
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:Diabetes mellitus is a major factor in clopidogrel resistance (CR), and the glucokinase (GCK) gene plays a pivotal role in glucose homeostasis. This study investigated the contribution of GCK polymorphisms to CR risk. METHODS:Two hundred SCAD patients were recruited, and their platelet functions were detect...
journal_title:Hematology (Amsterdam, Netherlands)pub_type: 杂志文章
doi:10.1080/16078454.2021.1945789
更新日期:2021-12-01 00:00:00